According to new research, brain estrogen levels might be increased by fatty acids in fish oil capsules, resulting in less seizures
As the CDC figures show, around 3.5 million adults and children in the U.S. are currently affected by epilepsy, a neurological condition resulting in regular seizures.
In latest research, scientists have noticed that epileptic seizures in mouse models were considerably reduced after administering fish oil medication.
Moreover, the docosahexaenoic acid (DHA) inside the fish oil supplements was observed to trigger a significant estrogen in their brains, suggesting that the combination of two substances is even more effective, despite the general consensus that estrogen has a few contraindications for these type of patients.
The 28 days long study focused on three oil-based treatments: soybean oil (rich in DHA), cottonseed oil and cottonseed oil plus DHA supplementation. After this period, the mice were induced controlled seizures and the researchers observed that the ones consuming soybean oil had the best response, as the occurrence and the duration of the seizures were lower than the ones belonging in the other two groups.
In addition, the team discovered that the estrogen levels in mice fed with soybean oil were double when compared with the group which ingested cottonseed oil and lower when compared with the ones fed with cottonseed oil diet supplemented with DHA.
The findings led to the speculation that the combination of substances can influence the seizure development. As a consequence, the scientists tested the dynamics of the symptoms by using the drug Letrozole in combination with cottonseed oil only or cottonseed oil and DHA supplements, resulting in better outcomes in the groups receiving estrogen.
The study was conducted by Dr. Yasuhiro Ishihara, from the Hiroshima University in Japan and published in the Scientific Reports journal.